Adenovirus May Cause Central Nervous System Disease in Children, Study Finds

A new study discovered more cases of adenovirus in the respiratory tract than the cerebrospinal fluid (CSF), however, most patients have the virus found in both.

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“The lack of adenovirus in the CSF does not exclude central nervous system (CNS) involvement,” the researchers said, adding that viral discovery results in the CSF do not seem useful as an indicator of the severity of CNS disease.


Retrograde analysis was performed on clinical, laboratory outcomes and the correlation between clinical characteristics and viral detection results in the CSF in children with adenovirus-related central nervous system (CNS) dysfunction.


What is an adenovirus?

Adenovirus is a common virus that can cause a range of illness. It can cause cold-like symptoms, fever, sore throat, bronchitis, pneumonia, diarrhea, and pink-eye (conjunctivitis). One can get or acquire adenovirus at any age.


During the study, there were 21 patients or 1.5 percent had adenovirus-related Central Nervous System (CNS) manifestations. Altered consciousness (100 percent) was the most frequently reported symptom which is followed by seizure (14.3 percent).


Fourteen patients (73.7 percent) and six (37.5 percent) had abnormal electroencephalogram examination and abnormal imaging, correspondingly.


Although none of the patients had been treated with cidofovir. Twenty of the patients recovered without sequelae and one died of respiratory failure.


Children with positive adenovirus polymerase chain reaction showed lower onset age than those with negative adenovirus polymerase chain reaction in the cerebrospinal fluid or CSF. There were no significant differences observed in clinical trial, laboratory findings, imaging studies and electroencephalogram.


Frequent etiology of acute respiratory tract infections, adenovirus is a rare cause of CNS disease in children, primarily causing altered consciousness. For the complete details of the medical study, you may check this link.


 

Source: Pediatr Infect Dis J 2021;40:205-208

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